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After the impact, the influx of Ca 2+ ions into the cell cytoplasm leads to the phosphorylation/activation of phospholipases that cleave phospholipids into fatty acids, diaglycerols and lysophospholipids like LPC, which initiates signaling cascades that drive inflammation, BBB destruction, demyelination, and protein aggregation in several neurodegenerative contexts [81]

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The rate accelerates slightly if you're in a structured calorie deficit, though semaglutide itself does much of the work by reducing hunger hormones

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Degree of weight loss, rather than the specific dietary strategy, was the primary determinant of clinical benefit